The assessment of early vascular effects of the angiogenesis inhibitor sunitinib in renal cell carcinoma (RCC) by DCE- MRI and diffusion weight MRI (DWI) at 3 Tesla
نویسندگان
چکیده
I. Desar, H. W. van Laarhoven, T. Hambrock, E. G. ter Voert, J. J. van Asten, D. van Spronsen, J. O. Barentsz, P. F. Mulders, A. Heerschap, and C. M. van Herpen Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, Radiology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, Medical Oncology, Canisius Wilhelmina Hospital, Nijmegen, Netherlands, Urology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
منابع مشابه
Functional MRI techniques demonstrate early vascular changes in renal cell cancer patients treated with sunitinib: a pilot study
OBJECTIVE To assess the early vascular effects of sunitinib in patients with renal cell carcinoma (RCC) with diffusion-weighted magnetic resonance imaging (DWI), dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and T2* perfusion MRI. PATIENTS AND METHODS In 10 patients with abdominal RCC lesions, DWI, DCE-MRI and T2* perfusion MRI measurements at 3 Tesla were performed at base...
متن کاملDynamic Contrast Magnetic Resonance Imaging (DCE-MRI) and Diffusion Weighted MR Imaging (DWI) for Differentiation between Benign and Malignant Salivary Gland Tumors
Background: Salivary gland tumors form nearly 3% of head and neck tumors. Due to their large histological variety and vicinity to facial nerves, pre-operative diagnosis and differentiation of benign and malignant parotid tumors are a major challenge for radiologists. Objective: The majority of these tumors are benign; however, sometimes they tend to transform into a malignant form. Functional M...
متن کاملCombining DCE-MRI and microbubble ultrasound to evaluate response to Sunitinib in patients with renal cell carcinoma
INTRODUCTION: As more anti-angiogenic drugs are developed, assessment of patient response during therapy is becoming crucial. DCE-MRI has been proposed as a way of detecting changes in the vasculature. For example, the Tofts model (1) provides the volume transfer constant, Ktrans, which describes permeability and flow, and ve, the extravascular, extracellular volume fraction. It has been shown ...
متن کاملRadiomics Analysis on FLT-PET/MRI for Characterization of Early Treatment Response in Renal Cell Carcinoma: A Proof-of-Concept Study1
Studying early response to cancer treatment is significant for patient treatment stratification and follow-up. Although recent advances in positron emission tomography (PET) and magnetic resonance imaging (MRI) allow for evaluation of tumor response, a quantitative objective assessment of treatment-related effects offers localization and quantification of structural and functional changes in th...
متن کاملMultiparametric MRI of solid renal masses: pearls and pitfalls.
Functional imaging [diffusion-weighted imaging (DWI) and dynamic contrast enhancement (DCE)] techniques combined with T2-weighted (T2W) and chemical-shift imaging (CSI), with or without urography, constitutes a comprehensive multiparametric (MP) MRI protocol of the kidneys. MP-MRI of the kidneys can be performed in a time-efficient manner. Breath-hold sequences and parallel imaging should be us...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009